Journal article
A novel approach to rapidly prevent age-related cognitive decline
PA Adlard, A Sedjahtera, L Gunawan, L Bray, D Hare, J Lear, P Doble, AI Bush, DI Finkelstein, RA Cherny
Aging Cell | WILEY | Published : 2014
DOI: 10.1111/acel.12178
Abstract
Summary: The loss of cognitive function is a pervasive and often debilitating feature of the aging process for which there are no effective therapeutics. We hypothesized that a novel metal chaperone (PBT2; Prana Biotechnology, Parkville, Victoria, Australia) would enhance cognition in aged rodents. We show here that PBT2 rapidly improves the performance of aged C57Bl/6 mice in the Morris water maze, concomitant with increases in dendritic spine density, hippocampal neuron number and markers of neurogenesis. There were also increased levels of specific glutamate receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-d-aspartate), the glutamate transporter (VGLUT1) an..
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Funding Acknowledgements
We thank Irene Volitakis for solution ICPMS analysis and Sarah Evans and Bruce Etherton for assistance with animal work. We are grateful to Professor Rudy Tanzi (Harvard Medical School, Massachusetts General Hospital) for discussions on this work. PAA, DIF, PD, RAC and DH are supported by funds from the National Health and Medical Research Council of Australia, The Australian Research Council and Prana Biotechnology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. PAA, RAC and DIF are shareholders and consultants to Prana Biotechnology. AB is a shareholder in Prana Biotechnology.